A daughter of ex-House Speaker Nancy Pelosi ripped into outgoing first lady Jill Biden over the weekend — seemingly comparing her to Shakespeare’s ruthless, power-hungry Lady MacBeth.

The first lady recently took a swipe at Pelosi over the Democratic mutiny against President Biden last summer, and Alexandra Pelosi, the lefty California congresswoman’s daughter, responded by saying her mom is actually one of the few friends Joe Biden has left.

“If I was Lady McBiden, I’d put on my big girl pants, play the long game and think about my husband’s legacy,” Alexandra snipped to Politico on Saturday.

“There aren’t that many people left in America who have something nice to say about Joe Biden, and Nancy Pelosi is one of them,” the younger Pelosi said.

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